Tofranil

Imipramine works by affecting the balance of certain chemicals in the brain, specifically serotonin and norepinephrine, which are involved in regulating mood. By increasing the levels of these chemicals, Tofranil helps to alleviate symptoms of depression and improve overall mood.

Medicine is available in tablet form.

How to use

Here are some general guidelines for using Tofranil:

1. Timing: Take medicine consistently at the same time(s) each day to maintain a steady level of the medication in your body. This helps optimize its effectiveness.
2. Swallowing: Swallow the tablets whole with a full glass of water. Do not crush, chew, or break the tablets. Breaking or crushing the tablets can alter their release mechanism and affect their efficacy.
3. Duration: Antidepressant may take several weeks to exert its full therapeutic effects. It is important to continue taking the medication as prescribed, even if you start feeling better.
4. Precautions: Some drugs and conditions can interact with Imipramine or require special monitoring.
5. Avoid alcohol: It is recommended to avoid or limit alcohol consumption while taking Tofranil, as it can increase the sedative effects of the medication.

Dosage

Depression:

• Adults: The usual starting dose for adults is 75 mg per day, divided into multiple doses. The dosage may be increased gradually, up to a maximum of 300 mg per day if necessary.
• Children and adolescents: The dosage for children and adolescents will be determined by the healthcare professional based on their weight and specific needs.

Enuresis (bedwetting):

• Children (6 years and older): The usual starting dose is 25 mg per day, taken one hour before bedtime. The dosage may be increased gradually, up to a maximum of 75 mg per day if needed.

Side effects

Tofranil may cause certain side effects, although not everyone experiences them. Here are some common side effects:

1. Dry mouth: This is a common side effect of Tofranil. Drinking water, chewing sugarless gum, or using a saliva substitute may help alleviate the discomfort.
2. Blurred vision: Medicine can affect your vision and cause blurred vision. Avoid activities that require clear vision, such as driving, until your vision returns to normal.
3. Drowsiness or dizziness: Tofranil may cause drowsiness or dizziness, especially when you first start taking the medication or when the dosage is increased. Avoid driving or operating heavy machinery if you experience these side effects.
4. Constipation: Imipramine can cause constipation. Consuming a diet high in fiber, drinking plenty of water, and staying physically active can help alleviate this side effect.
5. Urinary problems: Drug may affect the urinary system and lead to urinary retention or difficulty urinating.
6. Weight gain: Some individuals may experience weight gain while taking Tofranil. It is important to maintain a healthy diet and exercise routine to manage your weight.
7. Sexual side effects: Tofranil may cause changes in sexual desire, performance, or function.
8. Other common side effects: Other common side effects may include nausea, vomiting, headache, sweating, fatigue, and confusion.

Storage

To ensure the stability and effectiveness of Tofranil, it is important to store it properly. Here are some guidelines for storing:

1. Temperature: Store tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F).
2. Protect from moisture: Keep the medication in its original tightly closed container to protect it from moisture. Avoid storing it in areas with high humidity, such as the bathroom.
3. Avoid exposure to light: Protect Tofranil from excessive light exposure. Keep it in a dark place, away from direct sunlight or bright artificial light.
4. Keep out of reach of children: Store Imipramine in a secure location where children cannot access it. It is important to prevent accidental ingestion.
5. Follow expiration date: Check the expiration date on the packaging and do not use Tofranil beyond that date. Expired medications may not be as effective or safe to use.

If you have any unused or expired tablets, it is recommended to consult with a pharmacist or local waste disposal authorities on the appropriate disposal methods. Do not dispose of medications in the regular household trash or flush them down the toilet, as it can pose risks to the environment.

Overdose

An overdose of Imipramine can be potentially serious and requires immediate medical attention. If you suspect an overdose or have taken more than the prescribed dose of Tofranil, here's what you should do:

1. Seek emergency medical help: Contact your local emergency services or go to the nearest emergency room immediately. Prompt medical attention is crucial in case of an overdose.
2. Call your local poison control center: If available in your country, you can also call the national poison control helpline for guidance. They can provide further instructions on what steps to take.
3. Do not induce vomiting: Vomiting may not be effective or safe in cases of Tofranil overdose.
4. Provide information: When seeking medical assistance, provide accurate and detailed information about the medication, the dosage taken, and the timing of the overdose.
5. Medical management: Treatment for a Imipramine overdose typically involves supportive care to manage symptoms and stabilize vital signs. Depending on the severity of the overdose, medical professionals may employ techniques such as pumping the stomach (gastric lavage) or using activated charcoal to reduce absorption of the medication. Other measures, such as monitoring heart rhythm and providing respiratory support, may also be necessary.

It is crucial to remember that an overdose of Tofranil can have serious effects on the cardiovascular system, nervous system, and other body functions. It is important to seek immediate medical attention in such situations.

Missed Doses

If you miss a dose of Tofranil, here are some general guidelines to follow:

1. Take it as soon as you remember: If you realize you missed a dose and it is not close to the time of your next scheduled dose, take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
2. Do not take extra doses: Taking extra doses of Imipramine can increase the risk of side effects and may not provide additional benefit.
3. Maintain your regular dosing schedule: It is important to maintain a consistent dosing schedule for Tofranil to achieve optimal therapeutic effects. Resume taking the medication according to your usual schedule after a missed dose.
4. Do not abruptly stop taking Tofranil: Abruptly stopping Tofranil can lead to withdrawal symptoms and may impact the effectiveness of the treatment.